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Rafid A. Doulab

Rafid A. Doulab

University of Basra, Iraq

Title: Evaluation of elements impurities in drugs according to pharmacopoeia by use FESEM-EDS technique

Biography

Biography: Rafid A. Doulab

Abstract

Elemental Impurities in Pharmaceuticals industry is indispensable to ensure of pharmaceuticals safety, for 24 elements Although atomic absorption and inductively coupled plasma are used in the U.S Pharmacopeia and the European Pharmacopoeia, FESEM with energy dispersive spectrometers can be applied as an alternative analysis method for quantitative and qualitative results for a variety of elements without chemical pretreatment, unlike other techniques. This technique characterizes by shortest time, with less contamination, no reagent consumption and generation of minimal residue or waste as well as sample preparations time limiting, with minimal analysis error. Simple dilution for powder or direct analysis for liquid, we analyzed the usefulness of Energy Dispersive Spectrophotometry (EDS) method in testing with Field Emission Scanning Electron Microscopy (FESEM, SUPRA 55 Carl Zeiss Germany) with X-ray energy dispersion (XFlash 6-10 detector Germany). The samples analyzed directly without coating by applied 5 µ of known concentrated diluted sample on carbon stub with accelerated voltage according to sample thickness, the result for this spot was in atomic percentage and by Avogadro converted factor the final results will be in microgram.