Savita Dattatraya Patil
R. C. Patel Institute of Pharmaceutical Education & Research, India
Title: Glyoxylated pre-gelatinized starch used as novel excipient in pellet for the extended drug delivery: A statistical approach
Biography
Biography: Savita Dattatraya Patil
Abstract
The current study was aim to developed extended release (ER) pellets formulations containing zaltoprofen as a model drug and glyoxal treated starch hydrogel composite as a binder and extended release polymer. The glyoxal treated starch hydrogel composites were prepared using a 32 full factorial design approach and characterized by FTIR, DSC, XRD and SEM analysis. The matrix pellets were prepared by extrusion-spheronization technique and characterized production yield, FTIR, DSC, XRPD, SEM, optical microscopy, flow characteristics, mucoadhesiveness, in-vitro dissolution and in-vivo pharmacokinetic parameter. The FTIR interpretation of glyoxal treated starch hydrogel composite provides the significant result as a formation of hemiacetal group and keton group of glyoxal is abolished; hence it could be satisfied that star-κ-carr cross-linked hydrogel composite was formed. The optimized formulation (G5) was contained 4:8 ratio of glyoxal treated starch hydrogel composite showed in-vitro drug release up to 99.15 ± 2.20 %, 16h, respectively and in-vivo parameter were showed decrease in C max and increase in t1/2 significantly and drug release more than 12h. Hence it was concluded that optimized formulation (G5) showed acceptable release pattern, hence would be the viable alternative to ER type formulations.