Djebbar Atmani
University of Bejaia, Algeria
Title: Plant phenolics as new therapeutic agents in the treatment of diabetes and inflammation
Biography
Biography: Djebbar Atmani
Abstract
Phytochemicals, including phenolic compounds present in many plants have received much attention in recent years due to their health benefits. This study was conducted to investigate the anti-diabetic and anti-inflammatory activities of Pistacia and Fraxinus angustifolia, two plants traditionally used in Algerian folk medicine. The results indicated that P. lentiscus and F. angustifolia extracts, exhibited a promising anti-diabetic activity in streptozotocin (STZ)-induced diabetic rats, by a significant reduction (55%) of blood glucose level, a result confirmed by the inhibition of alpha-amylase activity (65%). The results of the anti-inflammatory activity of P. lentiscus and F. angustifolia showed significant reduction of the paw edema induced by carrageenan. Furthermore, P. lentiscus extracts showed a significant reduction of pro-inflammatory cytokines (IL-1β) in activated macrophages. Moreover, the extracts of F. angustifolia, significantly inhibited ear edema induced by single and multiple doses of 12-O-tetradecanoylphorbol 13-acetate (TPA) and suppressed the cellular infiltration. In vivo, the vesicles loaded with the crude extract of F. angustifolia and especially penetration enhancer-containing vesicles (PEV) inhibited oxidative stress in human keratinocytes against H2O2 and attenuated edema and leukocyte infiltration by stimulating the repair of TPA-induced skin damage. Chromatographic and spectroscopic analysis allowed the identification of known and new phenolic compounds, some of which are endowed with biological activities.