Maria A Miteva
University Paris Diderot, France
Title: Pharmacogenomics of cytochrome P450: Effects of missense mutations on drug metabolism
Biography
Biography: Maria A Miteva
Abstract
Pharmacogenomics investigates DNA and RNA variations in the human genome related to drug responses. Cytochrome P450 (CYP) is a supergene family of drug metabolizing enzymes responsible for the metabolism of approximately 90% of human drugs. Among the major CYP isoforms, the CYP2C subfamily is of clinical significance because it metabolizes approximately 20% of clinically administrated drugs and represents several variant alleles leading to adverse drug reactions or altering drug efficacy. Recent progress on understanding the inter-individual variability of the CYP2C members and the functional and clinical impact on drug metabolism will be presented. The structural bases and molecular mechanisms of amino acid variants of CYP2C members that affect drug metabolism will be discussed.