Tuba Aydin
Agri Ibrahim Cecen University, Turkey
Title: Inhibition effects of Tarragon (Artemisia dracunculus L.) extracts and its metabolites against the carbonic anhydrase I and II isozymes
Biography
Biography: Tuba Aydin
Abstract
Tarragon, Artemisia dracunculus L. is a small shrub and perennial plant species. It spreads in Japan, India, Iran, Europe, North America and China. The plant has several medicinal properties. It used in making vinegar and salad. In this study, five metabolites were isolated from dichloromethane extract from tarragon and their the chemical structure was characterized as anethole (1), β-stigmasterol (2), herniarin (3), (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide (4) and (2E,4E)-1- (piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one (5) by IR, 1D and 2D NMR spectroscopic methods. Enzyme inhibition activities of ethanol, dichloromethane, n-hexane and methanol extracts of A. dracunculus L. and all of the pure metabolites were investigated against human carbonic anhydrase I and II isoenzymes. Enzyme inhibition effects of the extracts and pure metabolites were evaluated by comparison of their IC50 values for the first time in this study. Our results showed that the extracts and the pure compounds of A. dracunculus L. were found to be strong inhibitor against the human carbonic anhydrase I and II isoenzymes. The compounds and extracts were showed in the range of 8.65-486.2 μM of IC50 values for Carbonic anhydrase I and II.