Tuba Aydin
Agri Ibrahim Cecen University, Turkey
Title: Effects of some natural compounds on the glutathione reductase enzyme
Biography
Biography: Tuba Aydin
Abstract
Discovery of Glutathione Reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some natural compounds, β-sitosterol, β-stigmasterol, diosgenin and jervine, which have steroidal skeleton, were reported. While β-stigmasterol was isolated from Artemisia dracunculus, β-sitosterol, diosgenin and jervine were isolated from rhizomes of Veratrum album. The chemical structures of the compounds were confirmed by IR, 1H-NMR, 13C-NMR, 1D and 2D NMR methods. The tested molecules were exhibited much potent inhibitory activities against GR at low micromolar concentrations with IC50 values ranging from 0.1916 to 5.2116 μM as compared with well-known agents. In this study first time, the inhibition effects of β-sitosterol, β-stigmasterol, diosgenin and jervine were determined on glutathione reductase enzyme.