Hulya Ozdemir
Yuzuncu Yil University, Turkey
Title: The effect of resveratrol therapy on serum total sialic acid and lipid-bound sialic acid in male rats with chronic fluorosis
Biography
Biography: Hulya Ozdemir
Abstract
Fluor is strongest electronegative element, a potent anion and cumulative toxin. This study was designed to evaluate the effect of resveratrol on serum total sialic acid (TSA) and lipid bound sialic acid in the rats chronically exposed to fluoride. The study was administered using 32 male Sprague Dawley rats weighing 200-250 g. Rats were divided into four groups (n=8/group). Group I comprised the control group, group II was treated with NaF (10 mg/lt/day), group 3 was treated resveratrol (50 mg/lt/day) and group IV was treated NaF+resveratrol for 90 days period. Total sialic acid (TSA) and lipid-bound sialic acid (LSA) were determined using spectrophotometric method. As a result of the analysis, It was seemed that LSA level compared with the control group increased in NaF group (p<0.05). On the other hand the resveratrol group was also significantly lower than the NaF group regarding LSA and TSA levels (p<0.05 and p<0.01 respectively). Whereas, the resveratrol + NaF group was significantly higher than the resveratrol group regarding TSA levels (p<0.05). Results from this study suggest that resveratrol may be partially effective in preventing the negative effects of fluorosis in male rats.