5^th Annual European Pharma Congress

Biography

Biography: Hulya Ozdemir

Abstract

This study was designed to investigate the effect of dietary boron on spatial learning, anxiety, some vitamin and oxidative parameter levels in rats given boric acid. Thirty two Wistar male rats average weight of 200 ± 20 g were used in this study. Rats were divided in four equal groups (n=8), control group fed with a standard rodent diet and experimental groups fed with 250, 500 and 1000 ppm boric acid enriched diet (equivalent to 4.1, 8.2 and 15.0 mg B/kg body weight). In a five-week long study the Elevated plus-maze was used for anxiety assessment and Morris water maze for evaluation of spatial learning. Additionally, blood samples were obtained at the end of the study and used to determine some vitamin and oxidative parameter levels. The dietary boron significantly increased weight gain (p<0.001) and food consumption in 250 and 500 ppm BA group (p<0.05). Although it did not affect learning process or anxiety related behaviour significantly, in 1000 ppm BA group it showed positive effects over memory consolidation (p<0.05). Biochemical analyses showed significant decrease of MDA (p<0.05) and increase of D3 vitamin levels (p<0.01) in 500 ppm BA group, significant increase in GSH-Px activity in 250 andrn500 ppm BA group (p<0.05) whereas vitamin E decreased in all groups (p<0.05). Total serum antioxidant capacity and retinol levels of experimental groups were not found significantly different. As a result, our study demonstrate that dietary boron in given doses has positive effects on performance of rats, memory consolidation, lipid peroxidation, glutathione peroxidase activity and vitamin D3 levels and, therefore, can be beneficial for health if used in right dosage notes: This article is written from a master‘s thesis of Bilyana Yaren and This research was supported by the Research Fund of the University of Centenary Year as Project No. 2010-SBE-YL137.rn