European Pharma Congress

Biography

Biography: Ozge Korkmaza

Abstract

Objective: Beta-blockers are a heterogeneous class of agents that are used in the treatment of many cardiovascular diseases, especially hypertension and atherosclerosis, and are commonly prescribed after cardiac surgery. In the present study, the aim is to investigate the vasorelaxant effects of some common beta adrenoseptor blockers on the human radial artery (RA) in vitro, as well as their relaxation mechanisms. Methods: RA rings sourced from human patients were mounted in an organ bath and tested for changes in isometric tension in relaxation response to labetalol, nebivolol and propranolol in the presence and absence of NG-nitro-L-arginine methyl ester (L-NAME, 3 x 10-5 mol/L) and tetraethyl ammonium (TEA, 3 x 10-4 mol/L). Results: The labetalol (10-8 to 10-4 mol/L), nebivolol (10-8 to 10-4 mol/L) and propranolol (10- 8 to 10-4 mol/L) induced concentration-dependent relaxations on the RA rings, which had been precontracted with phenylephrine (10-6 mol/L). The relaxation response induced by labetalol in the isolated RA rings was significantly higher when compared to the nebivolol and propranolol samples (p< 0.05). L-NAME significantly reduced the relaxation of nebivolol (p< 0.05) and TEA significantly reduced the relaxation of labetalol, nebivolol and propranolol (p < 0.05). Conclusion: We speculated that the relaxant effect of labetalol, nebivolol and propranolol was due partly to the Ca2+ -activated K+ channels. In addition, the relaxation induced by the nebivolol was largely related with nitric oxide release. Nebivolol, and partly propranolol, may provide significant therapeutic benefit, but Labetalol can be a good alternative for CABG with RA usage.