Monika Konaklieva
American University, USA
Title: b-Lactams cidal against Mycobacterium tuberculosis
Biography
Biography: Monika Konaklieva
Abstract
We have designed, synthesized, and tested monocyclic β-lactams that carry thiophenoxy group at C4. These thioethers have shown good intrinsic activity against serine β-lactamase producing Mycobacterium tuberculosis H37Rv (Mtb). Some of the compounds have demonstrated minimal inhibitory concentration (MIC) as low as 6.25 mg/ml in 7H9 and 1.5 mg/ml in GAST. Our investigations indicate that these compounds are cidal to both replicating and non-replicating persistent Mtb. These compounds have also shown activity against multi-drug resistant strains of M. tuberculosis. Therefore, they are promising candidates for lead discovery. Mechanism of action and target identification studies which are currently underway
