Biography
Man Hee Rhee graduated in Veterinary Medicine in 1989 and completed his MS degree in 1991 and then PhD degree in 2000 in Neurobiology Department, Weizmann Institute of Science, Israel. He then spent 3 years in the Department of Cell Biology & Physiology, Washington University School of Medicine, USA as a Research Associate. He has joined in Kyungpook National University as Associate Professor. He has published more than 150 papers in reputed journals and has been serving as an Editorial Board Member of repute.
Abstract
Ginseng, the root of Panax ginseng Meyer, had been used in Easter Asia, including Korea, China and Japan for a thousand of years. The potential benefits of ginseng range from energizing the body to providing the longevity. Ginsenoside Rg3 (Rg3), one of the most effective ginseng saponin, has anti-inflammatory and anti-cancer effects. Numerous previous studies have unraveled the Rg3 Pharmacological effects. One recent study has also revealed its protective cardiovascular effects in hyper sensitive rats. Here we investigated the anti-inflammatory activity of Rg3-enriched red ginseng extract in vitro on murine macrophages RAW 264.7 cells. We found that Rg3-enriched red ginseng extract in dose dependent manner attenuate the expression of proinflammatory cytokines after LPS induction. The MTT assay for dose dependent concentrations of Rg3-enriched red ginseng extract show no cytotoxicity and nitric oxide concentration show a decreasing trend with increase in dose. The mRNA expression of proinflammatory cytokines like IL-1β, IL-6, iNOS, COX-2 and TNF-α show the same trend like that of nitric oxide production. Furthermore, it was found that a remarkable attenuation of inflammation by oral treatment of Rg3-RGE extract in the mice survival study with LPS-induced septic shock. Rg3 enriched gingeng fraction can be hailed as a potent anti-inflammatory therapeutic agent in future.
Biography
Presenting author Dr. Namita NaikKhanvte is an Assistant professor at Visveswarapura Institute of Pharmaceutical Sciences, Bangalore-70, India. She is actively involved in research and guiding post-graduate students. She has one Indian patent to her credit.
Abstract
Helminthiasisis a macroparasitic disease of humans and animals in which a part of the body is infected with parasitic worms (helminthes) like tapeworms, flukes and round worms. There is a need to develop novel herbal formulation with minimum side effects for better patient compliance. Punica granatum L. Family Punicaceae, is an ancient, mystical, unique fruit. It is reported to have anthelmintic activity in previous literature. The objective of the present work was to develop a formulation convenient for administration and appealing to the patient. Difficulty in swallowing is common among geriatrics and pediatrics, hence to avert this problem, soft fruity chews containing a natural anthelmintic extract were formulated. Soft chews are pleasantly chewable dosage forms which offer an enjoyable mouth feel and chewing experience. They mask odors and provide a prolonged contact with mouth thus enhancing product acceptability in children and adults. The prototype jelly base was formulated using a gelling agent, preservative, flavoring agent, novel natural thickening agent, plasticizer, coloring and cooling agent (Ecocool MP). Finally, herbal extract (Punica Granatum) as anthelmintic was incorporated to this jelly base. The developed formulation was evaluated for quality control parameters like appearance, taste, texture and stability. The gummies satisfied the desired physicochemical properties. The formulation was subjected to in vitro anthelmintic activity on Pheretima posthuma and found to exhibit significant level of activity when compared with marketed formulation. Thus, soft fruity chews containing a herbal anthelmintic extract were successfully developed.